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KMID : 0361020140570020124
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Korean Journal of Otolaryngology - Head and Neck Surgery
2014 Volume.57 No. 2 p.124 ~ p.127
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New Treatment for Isolated Invasive Aspergillosis of Sphenoid Sinus in Immunocompetent Subjects: Sphenoid Nasalization Combined with Voriconazole
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Kim Dong-Kyu
Heo Sang-Taek
Kim Shin-Hye
Kim Dae-Woo
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Abstract
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Isolated invasive fungal sinusitis of sphenoid sinus in a healthy immunocompetent person is extremely rare. Classical treatment of invasive fungal sinusitis is wide sphenoidotomy and surgical debridement combined with antifungal agents, mostly amphotericin B. We describe a case of a 72-year-old immunocompetent woman who presented with deep-seated orbital pain and was diagnosed as isolated invasive aspergillosis in sphenoid sinus invading orbital apex and cavernous sinus. This case was treated successfully with a new combination treatment of sphenoid nasalization and voriconazole, a new antifungal agent. There was no evidence of postoperative recurrence and side effects during the usage of voriconazole.
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KEYWORD
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Invasive aspergillosis, Invasive fungal sinusitis, Sphenoid sinus, Sphenoidotomy, Voriconazole
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